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血凝集素样氧化低密度脂蛋白受体1(LOX-1)是氧化型低密度脂蛋白的主要受体,其在动脉粥样硬化的发生、发展机制中起着非常重要的介导作用,与急性冠状动脉综合征(ACS)的发病及进展密切相关,是目前研究的热点之一。现就LOX-1的特征与动脉粥样硬化发生、发展的关系,及其通过介导动脉粥样硬化斑块内细胞凋亡、削弱斑块纤维帽、促进炎性反应增强、同型半胱氨酸致动脉粥样硬化、促进血小板活化血栓形成等机制导致ACS进行综述。
Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) is the main receptor for oxidized low density lipoprotein, which plays a very important mediating role in the pathogenesis of atherosclerosis , Which is closely related to the onset and progression of acute coronary syndrome (ACS), is one of the hot spots in current research. Now on the characteristics of LOX-1 and atherosclerosis occurrence and development of the relationship between, and through its mediated apoptosis in atherosclerotic plaque, weakened plaque fiber cap, and promote increased inflammatory response, homocysteine Acid-induced atherosclerosis, and promote platelet activation thrombosis and other mechanisms lead to ACS review.