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一、蒽环类抗癌药物的发展 六十年代末进入临床的蒽环类化合物在肿瘤化疗中的地位愈来愈重要,成为四十年代应用性激素治疗乳腺癌和氮芥治疗恶性淋巴瘤,及五十年代末合成了环磷酰胺和氟脲嘧啶以来新的里程碑。柔红霉素对急性白血病有效,阿霉素对许多实体肿瘤有效,使肿瘤化疗在综合治疗中的地位有了相当提高。
1. Development of anthracycline-based anticancer drugs The status of anthracyclines entering the clinical setting in the late 1960s has become increasingly important in the development of cancer chemotherapy, and the use of sex hormones for the treatment of breast cancer and nitrogen mustard in the treatment of malignant lymphoma in the 1940s. In the late 1950s, new milestones have been synthesized for cyclophosphamide and fluorouracil. Daunorubicin is effective against acute leukemia, and doxorubicin is effective against many solid tumors, making the status of tumor chemotherapy more effective in comprehensive treatment.