目的：了解ＨＬＡＤＱＡ１基因型与乙型肝炎后肝硬化有无关联。方法：对３０例乙型肝炎后肝硬化住院患者的外周血ＤＮＡ，进行聚合酶链反应法扩增ＨＬＡＤＱＡ１基因第二外显子多态性片段，ｒ３２Ｐ末端标记８个序列特异性寡核苷酸，进行斑点杂交以确定ＨＬＡＤＱＡ１基因型，并与４０例正常人的结果进行比较。结果：ＨＬＡＤＱＡ１０１０２和Ａ１０３０１的频率在肝硬化组较高，但均未达到统计学意义。结论：ＨＬＡＤＱＡ１基因型与乙型肝炎后肝硬化的发生无明显关联 Objective: To understand HLA  DQA1 genotype and hepatitis B cirrhosis is related. Methods: Thirty patients with hepatitis B cirrhosis inpatients with peripheral blood DNA were amplified by polymerase chain reaction amplification of HLA-DQA1 gene exon 2 polymorphic fragments, r 32P end-labeled eight sequence-specific Oligonucleotides were hybridized to identify HLA-DQA1 genotypes and compared with the results of 40 normal individuals. Results: HLA  DQA1  0102 and A1  0301 frequency in cirrhosis group were higher, but did not reach statistical significance. Conclusion: The HLA-DQA1 genotype has no obvious correlation with the occurrence of post-hepatitis B cirrhosis