论文部分内容阅读
目的:探讨HIV感染者的淋巴细胞总数与CD4+T淋巴细胞数的相关性,以及其在监测疾病进展和高效抗逆转录病毒治疗疗效中的作用。方法:回顾性分析丽水市115例HIV感染者的294份全血标本中CD4+T淋巴细胞数和总淋巴细胞数的相关性。根据灵敏度、特异度、阳性预测值和阴性预测值预测CD4+T淋巴细胞数<200/μl和CD4+T淋巴细胞数<350/μl的总淋巴细胞数临界值。结果:丽水市HIV感染者的总淋巴细胞数同CD4+T淋巴细胞数显著相关(r=0.548,P(0.01)。用总淋巴细胞数<1500/μl预测CD4+T淋巴细胞数<200/μl,敏感性为68.42%、特异性为79.83%、阳性预测值为44.83%、阴性预测值为91.35%;用总淋巴细胞数<1800/μl预测CD4+T淋巴细胞数<350/μl,敏感性为67.44%、特异性为72.48%、阳性预测值为70.29%、阴性预测值为68.79%。结论:TLC和CD4+T计数的相关性与HIV感染者的年龄、病程阶段、有无合并机会感染等有关,用TLC预测CD4+T淋巴细胞数,仅仅是粗略估计,它可能更适用于HIV感染者个体动态监测其疾病进展、指导治疗等。
OBJECTIVE: To investigate the correlation between the total number of lymphocytes and the number of CD4 + T lymphocytes in HIV-infected individuals and their role in monitoring the progress of the disease and the efficacy of antiretroviral therapy. Methods: The correlation between the number of CD4 + T lymphocytes and the total number of lymphocytes in 294 whole blood samples from 115 HIV-infected persons in Lishui City was retrospectively analyzed. Predict the total number of lymphocytes with CD4 + T lymphocytes <200 / μl and CD4 + T lymphocytes <350 / μl based on the sensitivity, specificity, positive predictive value and negative predictive value. Results: The total number of lymphocytes in HIV-infected patients in Lishui City was significantly correlated with the number of CD4 + T lymphocytes (r = 0.548, P <0.01) .Total numbers of CD4 + T lymphocytes <200 / μl, the sensitivity was 68.42%, the specificity was 79.83%, the positive predictive value was 44.83%, the negative predictive value was 91.35%; the total lymphocyte count <1800 / μl predicted the CD4 + T lymphocyte count <350 / μl, 67.44%, specificity was 72.48%, positive predictive value was 70.29%, negative predictive value was 68.79% .Conclusion: The correlation between TLC and CD4 + T count and the age and course of HIV infection, with or without the merger opportunity Infection and other related, using TLC to predict the number of CD4 + T lymphocytes, only a rough estimate, it may be more suitable for HIV-infected individuals to dynamically monitor their disease progression, and guide the treatment.