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目的：研究突变型ｐ５３癌基因在垂体腺瘤中的表达。方法：应用免疫组化ＡＢＣ法检测６４例垂体腺瘤（复发组３１例，非复发组３３例），６例正常垂体、２例垂体癌中ｐ５３蛋白表达情况。结果：复发组中有１０例ｐ５３蛋白表达阳性，非复发组中有２例ｐ５３蛋白表达阳性，两组差异有显著性。２例垂体癌ｐ５３蛋白强阳性表达，６例正常垂体无阳性表达。ｐ５３蛋白在不同激素类型垂体腺瘤中的阳性表达率差异无显著性。结论：ｐ５３蛋白高表达与少数垂体腺瘤的潜在恶性及复发有关，与垂体腺瘤激素类型无关。
Objective: To study the expression of mutant p53 oncogene in pituitary adenomas. Methods: Immunohistochemical ABC method was used to detect the expression of p53 protein in 64 cases of pituitary adenoma (31 cases in recurrence group and 33 cases in non-recurrence group), 6 cases of normal pituitary and 2 cases of pituitary carcinoma. RESULTS: There were 10 cases of p53 protein positive in the recurrent group, and 2 cases of positive p53 protein in the non-relapse group. There was a significant difference between the two groups. Two cases of pituitary carcinoma had strong positive expression of p53 protein, and 6 cases of normal pituitary showed no positive expression. The positive expression rate of p53 protein in pituitary adenomas of different hormone types showed no significant difference. Conclusion: The high expression of p53 protein is associated with the potential malignant recurrence of a small number of pituitary adenomas and has nothing to do with the hormone type of pituitary adenomas.