鞭虫病是世界上重要的蠕虫病之一,多分布在热带和亚热带地区,个别地区发病率不亚于钩、蛔虫病,且常混合并存。鞭虫主要寄生在人体的盲肠,轻度感染时无症状,严重时可出现腹泻、胃肠道紊乱、杵状指、直肠脱垂、肠套叠、贫血和血便等。 驱鞭虫药,以往所用的四氯乙烯、槟榔煎剂等疗效欠佳;己烷雷琐辛灌肠则使用不便;碘化噻唑青胺、噻苯咪唑等副反应又较大;自甲苯咪唑问世后,曾被认为是治疗该病的首选药物,但疗程较长。近年来报道的驱鞭虫新药——酚嘧啶,1次服药即可见效,且副反应小,为目前最佳驱鞭虫药,现将国内外的研究情况,简介如下。 Trichurisercosis is one of the most important helminthiasis in the world, which is mainly distributed in tropical and subtropical regions. The incidence in individual areas is as high as that of hooks and ascariasis, and often mixed together. Whipworms mainly parasitic in the body’s cecum, asymptomatic mild infection, severe diarrhea, gastrointestinal disorders, clubbing, rectal prolapse, intussusception, anemia and bloody stool. Drift whip insecticide, the past use of tetrachlorethylene, betel decoction and other poor efficacy; hexane Lei Suoxi enema is inconvenient to use; thiazide iodine iodine, thiabendazole and other side effects and larger; come out of mebendazole After, was considered the drug of choice for the treatment of the disease, but a longer course of treatment. In recent years, reported whipworm new drug - phenol pyrimidine, a medication can be effective, and the side effects of small, is currently the best drive whip insecticide, now the research situation at home and abroad, are as follows.