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本院高血压专科门诊在1990年8月~1991年7月间发现由巯甲丙脯酸(开搏通)治疗引起间质性肺炎6例。1 临床资料男2例,女4例;年龄37~65岁,平均年龄52.7岁。其中3例开搏通与心痛定或双氢克尿塞合用,3例单用开搏通,开搏通剂量为12.5mg,每日2~3次,累计剂量175~700mg,平均累计剂量335.4mg。治疗期间患者出现刺激性干咳,以夜间为甚,不伴发热,心肺听诊无异常发现,以“上呼吸道感染”予头孢氨苄等治疗无效,周围血象显示嗜酸性
Hypertension specialist clinic in our hospital from August 1990 to July 1991 found that captopril (captopril) treatment caused by interstitial pneumonia in 6 cases. A clinical data of 2 males and 4 females; aged 37 to 65 years, mean age 52.7 years. Three of them were used with ketamine or hydrochlorothiazide, and three were used alone. The dose of Caifei was 12.5mg and the dosage was 175 ~ 700mg per day. The average cumulative dose was 335.4mg. During the treatment of patients with irritating dry cough, even at night, without fever, cardiopulmonary auscultation no abnormal findings, “upper respiratory tract infection” to cephalexin and other treatment is invalid, peripheral blood showed eosinophilic