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目的:对四家综合医院儿科住院病人及国内四种儿科杂志报道的儿童病人药物不良反应进行监测与分析,以期发现儿童病人药物不良反应发生的规律。方法:对1856例住院病人的药物不良反应进行前瞻性观察及对国内4种儿科杂志个例报道的药物不良反应360例的综合分析。结果:住院病人中107例发生了药物不良反应,发生率为5.8%。其中 A 型反应79例(73.8%),B 型28例(26.2%),药物不良反应致停药者48例,需处理者31例,致死者1例。因药物不良反应致住院者27例。不良反应发生率与住院时间、共用药物数量、疾病构成有关。小儿某些生理特征对药物不良反应发生有显著影响。结论:通过多中心监测的实践,认为在一般集中监测要求的基础上,建立协调中心,统一判定标准,参与人员的培训是协作监测的关键;儿童病人药物不良反应发生有某些特殊性。
OBJECTIVE: To monitor and analyze adverse drug reactions in pediatric inpatients and four pediatric pediatric patients reported in four general hospitals in order to find out the regularity of adverse drug reactions in children. Methods: Adverse reactions of 1856 inpatients were prospectively observed and 360 cases of adverse drug reactions reported in 4 pediatric journals were prospectively analyzed. Results: Among the hospitalized patients, 107 cases had adverse drug reactions, the incidence was 5.8%. Among them, 79 were type A (73.8%), 28 (26.2%) were type B, 48 were discontinued due to adverse drug reactions, 31 were needed for treatment, and 1 was fatal. 27 cases of inpatients due to adverse drug reactions. The incidence of adverse reactions and hospital stay, the number of drugs shared, the disease constitutes. Some physiological characteristics in children have a significant impact on adverse drug reactions. CONCLUSION: Through the practice of multicentre monitoring, it is considered that based on the general requirements for centralized monitoring, it is crucial to set up coordination center, uniform judgment standard and participant training as the key to collaborative monitoring. There are some particularities in children’s adverse drug reactions.