以尼泊金甲酯为初始原料,经甲基化、格氏试剂加成和醚化3步反应,设计合成了新型AB_3型树枝状标题化合物,利用红外光谱、核磁共振氢谱和元素分析对其结构进行了表征。对影响醚化反应的条件进行了优化,确定了最优反应条件:氢化钠为碱、四氢呋喃为溶剂、反应温度为65℃、反应时间为4 h,收率可达95%。 Using methylparaben as the starting material, a novel AB_3 dendritic compound was designed and synthesized by methylation, Grignard reagent addition and etherification in 3 steps. The compounds were characterized by IR, 1HNMR and elemental analysis Its structure was characterized. The conditions affecting the etherification reaction were optimized. The optimal reaction conditions were as follows: sodium hydride as base and tetrahydrofuran as solvent, the reaction temperature was 65 ℃, the reaction time was 4 h and the yield was 95%.