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降低胆固醇是否有益仍有争议。作者采用meta汇总分析法(meta analysis),报告随访二年以上的35项试验中胆固醇降低与冠心、非冠心和总死亡率的关系及干预方式。 资料与方法 入选标准:凡已发表的客观分析胆固醇降低与死亡率或冠心发病率关系的试验,观察时间≥2年均进入分析,共有35项试验。其中单因素预防试验共31项,包括单因素一级预防试验5项,单因素二级预防试验26项,多因素一级预防试验4项。一级分析指冠心病死亡率、非冠心病死亡率和总死亡率。冠心病死亡率反映了降低胆固
It is still debatable whether it is beneficial to lower cholesterol. The authors used a meta-analysis to report the association of cholesterol lowering with coronary heart disease, non-coronary heart disease, and overall mortality in 35 trials followed up for more than two years and the intervention modalities. Materials and Methods Inclusion criteria: All published trials that objectively analyzed the association between cholesterol reduction and mortality or coronary heart disease were included in the analysis for> 2 years, with a total of 35 trials. There were 31 single factor prevention trials, including 5 single factor primary prevention trials, 26 single factor secondary prevention trials and 4 multifactorial primary prevention trials. A primary analysis of coronary heart disease mortality, non-coronary heart disease mortality and total mortality. Coronary heart disease mortality reflects reduced cholesterol