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以前的研究已经表明补充外源性甲地孕酮、hCG可以翻转咖啡酸的抗早孕作用,推测咖啡酸具有抗孕激素活性,但对孕激素受体没有影响。本文研究了咖啡酸对小鼠假孕维持时间、血浆孕酮水平、卵巢孕酮合成酶、子宫蜕膜细胞反应等多方面的影响,以确证咖啡酸的抗孕激素活性,从而进一步阐明咖啡酸抗早孕作用机理。实验表明,小鼠假孕第6、7、8天,每天两次口服咖啡酸(10mg/kg),可显著缩短小鼠假孕维持时间(P<0.01)。我们利用假孕小鼠、线刺激诱发蜕膜反应(DCR)的模型,
Previous studies have shown that supplementation of exogenous megestrol, hCG can turn caffeic acid anti-early pregnancy effect, suggesting that caffeic acid has anti-progesterone activity, but no effect on progesterone receptors. This article studies the effects of caffeic acid on the duration of pseudopregnancy in mice, plasma progesterone level, progesterone synthase in ovary and uterine decidual cell response in order to confirm the anti-progesterone activity of caffeic acid, Anti-pregnancy mechanism of action. Experiments show that mice on the 6th, 7th and 8th day of pregnancy, twice daily oral administration of caffeic acid (10mg / kg), can significantly reduce the duration of pregnancy (P <0.01). Using pseudopregnant mice, we stimulated a model of line-induced decidual reaction (DCR)