应用流式细胞免疫学技术对58例肿瘤患者手术前后外周血小板活化分子P-选择素和凝血酶敏感蛋白进行了对比研究。结果术后外周血P-选择素及凝血酶敏感蛋白较术均明显增加，有统计学意义。其中P-选择素增加更为显著（P<0．01）。男性患者术前后血小板活化状态较女性患者更为明显。本研究提示手术对癌症患者血小板有明显的活化作用，在男性更为显著，应重视手术后的防凝措施，防止血栓病的发生。 The flow cytometric immunology technique was used to compare the platelet activation molecules P-selectin and thrombospondin-sensitive proteins in 58 patients with tumor before and after surgery. Results Postoperative peripheral blood P-selectin and thrombospondin-sensitive protein were significantly higher than those of the other two groups. Among them, P-selectin increased more significantly (P<0.01). The preoperative and postoperative platelet activation in male patients were more pronounced than in female patients. This study suggests that surgery has a significant activation of platelets in cancer patients, more prominent in men, should pay attention to post-operative anti-coagulation measures to prevent the occurrence of thrombosis.