目的探讨单鼻孔经蝶入路切除垂体瘤的手术技巧。方法对27例采用该入路手术治疗的垂体瘤病人临床资料进行回顾性分析。结果27例患者中肿瘤全切除24例,大部分切除3例,18例分泌腺瘤病人中,术后激素水平降至正常13例,2例暂时性尿崩。结论此术式手术路径短、术后并发症少、恢复快。经单鼻孔蝶窦入路显微手术是垂体腺瘤治疗的理想的方法。 Objective To investigate the surgical techniques of single nostril transsphenoidal surgery for pituitary tumor resection. Methods The clinical data of 27 cases of pituitary adenoma treated by this approach were analyzed retrospectively. Results Of the 27 patients, 24 were resected completely, 3 were mostly resected, and in 18 patients with secreted adenoma, the postoperative hormone levels were reduced to normal in 13 and transient insipidus in 2. Conclusion This surgical procedure is short, less postoperative complications and faster recovery. Microsurgery through the single nostril sphenoid sinus approach is an ideal method for the treatment of pituitary adenomas.