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本文对不同孕期妇女、妊高征患者及分娩后第5天产如分别进行血浆凝血活性测定。每一标本均测定纤维蛋白原、凝血因子活性Ⅱ∶C、Ⅴ∶C、Ⅷ∶C、Ⅸ∶C、Ⅹ∶C、Ⅺ∶C、Ⅻ∶C及因子Ⅷ相关抗原(ⅧR∶Ag)、因子ⅩⅢα∶Ag、ⅩⅢβ∶Ag。测定结果:早孕妇女血浆凝血因子Ⅴ∶C水平升高(P<0.05),其余与非孕对照组无显著差异。孕中期妇女血浆凝血因子Ⅴ∶C、Ⅶ∶C、Ⅷ∶C、ⅧR∶Ag、Ⅹ∶C和Ⅻ∶C都明显升高(P<0.01或P<0.001),其余凝血因子无变化。孕晚期妇女大多数凝血因子都升高,Ⅻ∶C无变化而因子ⅩⅢα∶Ag则有所下降。妊高征患者比同孕期晚孕妇女变化更明显。分娩后几乎所有凝血因子均升高,而因子ⅩⅢα∶Ag则下降。
In this paper, different pregnant women, patients with pregnancy induced hypertension and postnatal day 5, such as plasma coagulation activity were measured. Fibrinogen and coagulation factor activities were measured in each specimen. The activities of factor Ⅷ: C, Ⅴ:C, Ⅷ:C, Ⅸ:C, Ⅹ:C, Ⅺ:C, Ⅻ:C and factor Ⅷ related antigen (ⅧR: Ag) Factor XIII alpha: Ag, XIII beta: Ag. The results showed that the plasma coagulation factor Ⅴ: C level increased in early pregnant women (P <0.05), while the rest had no significant difference with non-pregnant control group. The levels of plasma coagulation factors Ⅴ: C, Ⅶ:C, Ⅷ:C, ⅧR: Ag, Ⅹ:C and Ⅻ: C in the second trimester women were significantly increased (P <0.01 or P <0.001), while the rest of the clotting factors were unchanged. Most women in the second trimester of blood coagulation factors are elevated, Ⅻ: C unchanged and factor XIII α: Ag decreased. Pregnancy-induced hypertension than pregnant women in late pregnancy more obvious changes. Almost all clotting factors increased after delivery, whereas factor XIIIa: Ag decreased.