输入 LAK 细胞的被动免疫疗法即 LAK 细胞过继免疫疗法,是1984年由美国 NCI(国立癌研究所)的Rosenberg 等建立的。以后在欧洲和日本也进行了这方面的研究。一、IL—2·LAK 疗法的现状Rosenberg 等使用的方案是将 IL-2(分次、大剂量)全身给药后,用细胞分离器收集淋巴细胞(一次5×10~9～5×10~(10)个),将此细胞和 IL-2(1500U/ml) Passive immunotherapy for LAK cells, ie, LAK cell adoptive immunotherapy, was established in 1984 by Rosenberg et al. of the National Cancer Institute (NCI). Later in Europe and Japan also conducted this research. First, the status of IL-2 LAK therapy The protocol used by Rosenberg et al. is to use IL-2 (fractionated, large dose) systemically administered to collect lymphocytes with a cell separator (5×10~9~5×10 at a time) ~ (10)), cells and IL-2 (1500 U/ml)