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用小鼠白血病病毒ＬＰ－ＢＭ５ＭｕＬＶ接种新生ＢＡＬＢ／Ｃ小鼠，感染后４～６个月可出现与人类ＡＩＤＳ极为相似的病理变化和免疫缺陷的症状，包括血免疫球蛋白增高、淋巴结肿大、Ｔ辅助淋巴细胞减少和淋巴细胞转化功能降低等。通常作为小鼠获得性免疫缺陷综合症即小鼠艾滋病（ＭＡＩＤＳ）的模型使用。本实验采用已证实具有溶瘤作用的鹿肠道病毒ＥＣＣＯ－１８株对小鼠艾滋病进行实验性治疗，结果表明鹿肠道病毒ＥＣＣＯ－１８可明显缓解艾滋病小鼠的淋巴结肿大和延长艾滋病小鼠的生存时间。提示鹿肠道病毒ＥＣＣＯ－１８治疗小鼠艾滋病有效。
Inoculation of newborn BALB / C mice with the leukemia virus LP-BM5MuLV showed signs of pathological changes and immunodeficiency similar to human AIDS 4 to 6 months after infection, including increased immunoglobulin, enlarged lymph nodes, T-helper lymphopenia and decreased lymphocyte transformation function. It is commonly used as a model for mouse acquired immunodeficiency syndrome, Mouse AIDS (MAIDS). In this experiment, the experiment has been carried out on mice with AIDS virus by demonstrating oncolytic activity of the enterovirus ECCO-18 strain. The results showed that the enterovirus ECCO-18 can significantly alleviate the AIDS-induced lymph node enlargement and prolonged AIDS in mice The survival time. Tip deer enterovirus ECCO-18 treatment of AIDS in mice.