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1型糖尿病是以胰岛 β细胞破坏为特征 ,由T细胞介导的自身免疫性疾病 ,β细胞凋亡在其发病中起一定的作用 ,Fas FasL系统参与 β细胞凋亡。Fas由死亡诱导信号复合物 (DISC)或前配体结合聚集区 (PLADS)作用途径形成三聚体来传递凋亡信号。由浸润的T淋巴细胞、巨噬细胞等分泌的细胞因子包括白介素 (IL) 1β、肿瘤坏死因子 (TNF) α、干扰素 (IFN) γ直接或间接通过诱导一氧化氮 (NO)合酶产生高浓度NO而对β细胞起破坏作用。对于 β细胞破坏机制的研究可能为 1型糖尿病的防治提供新的措施。
Type 1 diabetes is an autoimmune disease characterized by destruction of islet beta cells, mediated by T cells. Beta-cell apoptosis plays a role in its pathogenesis, and Fas FasL system is involved in beta-cell apoptosis. Fas forms trimers through death-inducing signaling complex (DISC) or pro-ligand binding aggregation (PLADS) pathway of action to deliver apoptotic signals. Cytokines secreted by infiltrating T lymphocytes, macrophages and the like include interleukin (IL) 1β, tumor necrosis factor (TNF) α, interferon (IFN) γ produced directly or indirectly by induction of nitric oxide synthase High concentrations of NO play a destructive role in the beta cells. Research on the mechanism of β-cell destruction may provide new measures for the prevention and treatment of type 1 diabetes.