[目的]探讨康复新液保留灌肠治疗溃疡性结肠炎(UC)的临床疗效。[方法]将67例UC患者随机分为对照组和治疗组,对照组服用美沙拉嗪治疗,治疗组在对照组基础上加用康复新液保留灌肠,2组治疗30天后观察对比其疗效和血清细胞因子IL-1、IL-8、TNF-α的变化。[结果]2组患者的有效率比较差异无统计学意义,但显效率和细胞因子的变化比较差异有统计学意义。[结论]康复新液灌肠治疗溃疡性结肠炎,其疗效显著、确切而且安全。 [Objective] To investigate the clinical efficacy of Kangfuxin solution retention enema in the treatment of ulcerative colitis (UC). [Methods] 67 patients with UC were randomly divided into control group and treatment group. The control group was treated with mesalazine. The treatment group was treated with Kangfuxinye retention enema on the basis of the control group. The therapeutic effect and Changes of serum cytokines IL-1, IL-8 and TNF-α. [Results] There was no significant difference in the effective rate between the two groups, but the difference between the markedly effective rate and the change of cytokines was statistically significant. [Conclusion] Kang Fu Xin Li enema treatment of ulcerative colitis, the curative effect is obvious, exact and safe.