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目的探讨复方鳖甲软肝片联合阿德福韦酯对慢性乙型肝炎肝纤维化的临床疗效。方法选择明确诊断为乙型肝炎肝纤维化的患者92例,随机分为对照组和观察组,对照组给予常规保肝治疗,观察组给予复方鳖甲软肝片联合阿德福韦酯治疗,24周后观察疗效。结果观察组与对照组治疗24周后,各种血清生化指标变化比较差异有统计学意义(P<0.05);两组在显效与无效病例方面比较差异有统计学意义(P<0.01)。结论复方鳖甲软肝片联合阿德福韦酯治疗慢性乙型肝炎肝纤维化安全性良好,疗效确切,是治疗和预防肝纤维化的一种切实有效的方法。
Objective To investigate the clinical efficacy of Fufang Biejia Ruangan Pian combined with adefovir dipivoxil in treatment of chronic hepatitis B liver fibrosis. Methods Ninety-two patients with definite diagnosis of hepatitis B-induced liver fibrosis were randomly divided into control group and observation group. The control group was given conventional hepatoprotective therapy. The observation group was given Fufang Biejia Ruangan Pian combined with adefovir dipivoxil, After 24 weeks to observe the effect. Results After 24 weeks of treatment, the changes of serum biochemical indexes in the observation group and the control group were statistically significant (P <0.05). There was significant difference between the two groups in the effective and ineffective cases (P <0.01). Conclusion Fufang Biejia Ruangan Pian combined with adefovir dipivoxil is safe and effective in treating chronic hepatitis B with liver fibrosis. It is an effective and effective method for the treatment and prevention of liver fibrosis.