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2017年5月26日,《Cell》期刊在线发表一篇题为“Regulatory T cells in skin facilitate epithelial stem cell differentiation”的文章报道一个意料之外的研究成果:免疫细胞直接参与毛囊的再生,且其功能紊乱会导致“秃顶”。这一研究成果由来自加州大学旧金山分校的研究小组完成。Rosenblum及其团队以小鼠为模型研究发现,调节性T细胞可直接激活皮肤中的干细胞,促进毛发生长。如果调节性T细胞失效,毛囊将无法再生,从而导致脱发。与其他免疫细胞一样,大多数调节性T细胞都存在于淋巴结中,但是依然有少量细胞位于其他部位,负责协助这些部位的免疫调节。Rosenblum及其团队之前的研究成果表明,皮肤中的调节性T细胞有助于
On May 26, 2017, an article online online entitled “Regulatory T cells in skin facilitating epithelial stem cell differentiation” published in the journal Cell reported an unexpected finding: Immune cells are directly involved in the regeneration of hair follicles, And its dysfunction causes “bald ”. The research was completed by a research team from the University of California, San Francisco. Rosenblum and his team used mouse models to find that regulatory T cells activate stem cells directly in the skin and promote hair growth. If regulatory T cells fail, the hair follicles will not regenerate, causing hair loss. Like other immune cells, most regulatory T cells are present in the lymph nodes, but a small number of cells are still located elsewhere and are responsible for assisting immunomodulation at these sites. Previous research by Rosenblum and his team showed that regulatory T cells in the skin help