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目的探讨低级别上皮内瘤变(LGN)与慢性胃炎的关系,评价胃复春联合治疗逆转LGN的疗效。方法49例胃镜病理活检诊断为慢性胃炎伴LGN患者,随机分为两组,对照组(n=24)单用胃复春治疗,治疗组(n=25)采用胃复春、叶酸和阿司匹林联合治疗,疗程均为3个月,之后复查胃镜及病理活检。结果复查胃镜及活检显示,21例上皮内瘤消失仅为慢性胃炎,1例仍为慢性胃炎伴LGN;26例合并肠化生者中2例肠化生消失,29例合并萎缩者中8例萎缩消失,5例重度胃炎患者中4例转为轻中度胃炎。慢性胃炎合并LGN患者中,治疗组治疗效果值高于对照组(1.44±0.71对1.08±0.28),差异具有统计学意义(P<0.05);治疗组显效率亦高于对照组(32%对8.33%),差异具有统计学意义(P<0.05)。结论各类慢性胃炎可合并LGN。药物治疗有助于逆转LGN,且胃复春联合叶酸、阿司匹林治疗效果明显优于胃复春单药治疗。
Objective To investigate the relationship between low-grade intraepithelial neoplasia (LGN) and chronic gastritis and to evaluate the efficacy of Weifuchun combined therapy in reversing LGN. Methods Forty-nine patients with chronic gastritis and LGN were diagnosed by gastroscopic pathology biopsy and divided into two groups randomly. The control group (n = 24) was treated with Weifuchun alone. The treatment group (n = 25) was treated with Wefuchun, folic acid and aspirin Treatment, treatment are 3 months, after review of endoscopy and biopsy. The results of gastroscopy and biopsy showed that 21 cases of intraepithelial neoplasia disappeared only chronic gastritis, 1 case of chronic gastritis with LGN; 26 cases of intestinal metaplasia in 2 cases of intestinal metaplasia disappeared, 29 cases with atrophy in 8 cases Atrophy disappeared, 5 cases of severe gastritis in patients with mild to moderate gastritis. Chronic gastritis with LGN patients, the treatment group was higher than the control group (1.44 ± 0.71 vs 1.08 ± 0.28), the difference was statistically significant (P <0.05); the treatment group was also significantly higher than the effective rate of the control group (32% 8.33%), the difference was statistically significant (P <0.05). Conclusion Various types of chronic gastritis may be associated with LGN. Drug treatment can help reverse LGN, and Wei Weichun combined folic acid, aspirin treatment was significantly better than Wei Fuchun monotherapy.