论文部分内容阅读
目的：观察海藻硫酸多糖（ＳＰ）对正常及荷瘤小鼠肝匀浆及红细胞中ＳＯＤ，ＧＳＨ－Ｐｘ活性及脂质过氧化产物ＭＤＡ含量的影响，探讨其抗氧化与抗肿瘤之间的关系。结果：移植肿瘤Ｓ１８０使肝组织中ＳＯＤ，ＧＳＨ－Ｐｘ活性分别由１１３．７３±８．１７降至７１．４１±１０．９８ｍｇ／Ｌ（Ｐ＜０．０５），３２．３４±０．０５降至２９．９６±０．１６Ｕ（Ｐ＜０．０１），ＭＤＡ含量由０．２３４±０．００１增至０．２８０±０．０１２（Ｐ＜０．０５），腹腔注射或口服ＳＰ则使ＳＯＤ，ＧＳＨ－Ｐｘ活性增至１１８．７７±１８．９２ｍｇ／Ｌ（Ｐ＜０．０５），３６．５８±１．０６Ｕ（Ｐ＜０．０１），ＭＤＡ含量降至０．１０４±０．０３９（Ｐ＜０．０１）。且腹腔注射ＳＰ１００ｍｇｋｇ－１ｄ－１×１０ｄ可使肿瘤抑制率达３９．１３％，口服ＳＰ２００ｍｇｋｇ－１ｄ－１×１０ｄ也能使肿瘤抑制率达２８．０４％。结论：ＳＰ抑瘤作用的机理可能与抗氧化有关。
Objective: To observe the effect of seaweed sulfate polysaccharide (SP) on the activity of SOD, GSH-Px and the content of lipid peroxidation product in the liver homogenates and erythrocytes of normal and tumor-bearing mice, and to explore the relationship between anti-oxidation and anti-tumor . Results: The activity of SOD and GSH-Px in the liver tissue was reduced from 113.73 ± 8.17 to 71.41 ± 10.98mg / L (P <0.05) and 32.34 ± 0.05 Decreased to 29.96 ± 0.16U (P <0.01), the content of MDA increased from 0.234 ± 0.001 to 0.280 ± 0.012 (P <0.05), and the intraperitoneal injection or oral SP The activity of SOD and GSH-Px increased to 118.77 ± 18.92mg / L (P <0.05), 36.58 ± 1.06U (P <0.01), MDA content decreased to 0.104 ± 0 .039 (P <0.01). And the intraperitoneal injection of SP100mgkg-1d-1 × 10d tumor suppression rate was 39.13%, oral SP200mgkg-1d-1 × 10d also make the tumor inhibition rate of 28.04%. Conclusion: The mechanism of anti-tumor effect of SP may be related to anti-oxidation.