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目的:探讨黄芪注射液对高果糖饮食大鼠胰岛素抵抗和氧化应激的抑制作用。方法:SD大鼠经高果糖饲料喂养4周后,随机分为模型组,黄芪注射液高、低剂量(相当于生药量ip 5,2.5 g.kg-1)组、罗格列酮(3 mg.kg-1,ig)组,连续给药4周,继续给予高果糖饲料4周。同时设立正常组,普通饲料喂养。测定体重、空腹血糖、血浆胰岛素、胰岛素抵抗指数、氧化应激指标。结果:模型组体重与正常组无明显区别;空腹血糖、血浆胰岛素水平、胰岛素抵抗指数、丙二醛(MDA)含量明显高于正常组(P<0.05);过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性显著低于正常组(P<0.05)。与模型组相比,黄芪注射液组、罗格列酮组空腹血糖、血浆胰岛素水平、胰岛素抵抗指数、MDA含量降低,CAT,SOD,GSH-Px活性升高,高剂量组与模型组比较有显著性差异(P<0.05)。结论:黄芪注射液可减轻高果糖饮食所引起的胰岛素抵抗及氧化应激。
Objective: To investigate the inhibitory effect of Astragalus injection on insulin resistance and oxidative stress in rats with high fructose diet. Methods: SD rats were fed with high fructose diet for 4 weeks and then were randomly divided into model group, Astragalus injection high and low dose (equivalent to crude drug dose ip5,2.5 g.kg-1), rosiglitazone (3 mg.kg-1, ig) group, continuous administration for 4 weeks, continue to give high fructose feed for 4 weeks. At the same time set up a normal group, ordinary feed. Body weight, fasting blood glucose, plasma insulin, insulin resistance index and oxidative stress were measured. Results: There was no significant difference between the model group and the normal group (P <0.05). The levels of fasting blood glucose, plasma insulin, insulin resistance index and malondialdehyde (MDA) The activities of SOD and GSH-Px were significantly lower than those of the normal group (P <0.05). Compared with the model group, the fasting blood glucose, plasma insulin, insulin resistance index, MDA content, CAT, SOD, GSH-Px activity increased in Astragalus injection group and rosiglitazone group compared with the model group Significant difference (P <0.05). Conclusion: Astragalus injection can reduce insulin resistance and oxidative stress caused by high fructose diet.