论文部分内容阅读
腈类和氰化物之間-CN的交換,不但理論上是有趣的問題,同时在应用上也是有实际意义。假如C~(14)标记的氰化物可以和腈类起交換作用,交换后将腈化物水解就应該得到C~(14)标記的有机酸(RC~(14)OOH),这样就比一般用格氏試剂制备标記的有机酸的方法方便得多了。蔡馏生和Kamen曾经研究C~(14)标记的氰化物和CH_3CN,C_6H_5CN,(CH_2)_2(CN)_2的交換,所得的结果指明在75-100℃的温度下基本上不起交換作用(交换小于1%),考虑到增加温度可能促使交换反应的进行,因此本实驗即在200℃的高温下进行,所用的实验条件和方法也有所不同,但是实驗的結果仍然沒有显著的交換。
The exchange of nitrile and cyanide between the -CN, not only theoretically interesting issues, but also practical significance. If the C ~ (14) labeled cyanide can exchange with the nitrile, the C ~ (14) labeled organic acid (RC ~ (14) OOH) should be obtained after the exchange. The general method of preparing labeled organic acids with Grignard reagents is much more convenient. Cai Chansheng and Kamen studied the exchange of C 14 labeled cyanide with CH 3 CN, C 6 H 5 CN, (CH 2) 2 CN 2, and the results indicated that the exchange could not be performed at a temperature of 75-100 ° C. (Exchange less than 1%). Considering that increasing the temperature may promote the exchange reaction, the experiment was carried out at a high temperature of 200 ° C. Experimental conditions and methods used were different. However, there was still no significant exchange of experimental results.