【摘 要】
：
CD8+ T lymphocytes are pivotal cells in the host response to antitumor immunity.Tumor-driven microenvironments provide the conditions necessary for regulating infiltrating CD8+ T cells in favor of tumor survival,including weakening CD8+ T cell activation,
【机 构】
：
College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310012,China;Division of Anti-Tumor
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CD8+ T lymphocytes are pivotal cells in the host response to antitumor immunity.Tumor-driven microenvironments provide the conditions necessary for regulating infiltrating CD8+ T cells in favor of tumor survival,including weakening CD8+ T cell activation,driving tumor cells to impair im-mune attack,and recruiting other cells to reprogram the immune milieu.Also in tumor microenviron-ment,stromal cells exert immunosuppressive skills to avoid CD8+ T cell cytotoxicity.In this review,we explore the universal function and fate decision of infiltrated CD8+ T cells and highlight their anti-tumor response within various stromal architectures in the process of confronting neoantigen-specific tu-mor cells.Thus,this review provides a foundation for the development of antitumor therapy based on CD8+ T lymphocyte manipulation.
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