【摘 要】
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The initiation and development of major inflammatory diseases,i.e.,cancer,vascular inflam-mation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immu-notherapy is exerting a critical role against these diseases,whereas
【机 构】
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School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Key Laboratory of Modern Pre
论文部分内容阅读
The initiation and development of major inflammatory diseases,i.e.,cancer,vascular inflam-mation,and some autoimmune diseases are closely linked to the immune system.Biologics-based immu-notherapy is exerting a critical role against these diseases,whereas the usage of the immunomodulators is always limited by various factors such as susceptibility to digestion by enzymes in vivo,poor penetration across biological barriers,and rapid clearance by the reticuloendothelial system.Drug delivery strategies are potent to promote their delivery.Herein,we reviewed the potential targets for immunotherapy against the major inflammatory diseases,discussed the biologics and drug delivery systems involved in the immunotherapy,particularly highlighted the approved therapy tactics,and finally offer perspectives in this field.
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