最近,Mazanec等提出转运内吞中的IgA分子可与进入细胞的病毒形成复合物,从而抑制病毒在细胞内增殖的体外模型。为了确定体内非中和抗体能否介导细胞内效应,用小鼠研究IgA单克隆抗体对轮状病毒感染的作用。作者用分泌抗轮状病毒VP6、 Recently, Mazanec et al. Proposed an in vitro model in which IgA molecules involved in transport endocytosis can form complexes with viruses that enter cells, thereby inhibiting the proliferation of viruses in cells. To determine whether in vivo non-neutralizing antibodies could mediate intracellular effects, mice were used to study the effect of IgA monoclonal antibodies on rotavirus infection. The authors used the secretion of anti-rotavirus VP6,