流感病毒感染后可损伤人呼吸道内皮细胞,并能诱导体外培养的哺乳动物细胞凋亡,但流感病毒能否诱导体内细胞凋亡及其作用机制尚不明确。本文作者用流感病毒A/PR/8/34株10~3pfu(4LD_(50))接种小鼠右鼻腔后,全部动物出现严重呼吸道症状,其中82.2%于7d内死亡。肺脏、脾脏和胸腺等器官的病理切片显示肺支气管、细支气管和肺泡结构 Influenza virus infection can damage human respiratory tract endothelial cells, and can induce apoptosis in mammalian cells cultured in vitro, but the influenza virus can induce apoptosis in vivo and its mechanism of action is not yet clear. After inoculating the right nasal cavity of mice with 10-3pfu (4LD_ (50)) of influenza virus A / PR / 8/34 strain, all the animals developed severe respiratory symptoms, of which 82.2% died within 7 days. Lung, spleen and thymus and other organs of the pathological lung showed bronchus, bronchioles and alveolar structure