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作者将60例Ⅲ期NSCLC随机分组,其中30例先行FOP方案化疗,两周期后给予放疗;30例单纯放疗。结果显示:化放组总有效率和完全缓解率分别为66.7%和30%,单放组为53.3%和20%;化放组3年生存率、局控率及远处转移率分别是16.7%、20%和33.3%,单放组为10%、10%和43.3%。化疗的毒副作用主要是胃肠道反应和骨髓抑制,放疗的毒副作用主要是放射性食管炎、肺炎和肺纤维化。
The authors randomized 60 cases of stage III NSCLC, including 30 cases of FOP regimen chemotherapy, two cycles of radiotherapy, and 30 cases of radiotherapy alone. The results showed that the total effective rate and complete remission rate were 66.7% and 30% in the release group, 53.3% and 20% in the radiotherapy group, and the 3-year survival rate, local control rate, and distant metastasis of the chemotherapy group. The rates were 16.7%, 20% and 33.3%, respectively, and 10%, 10% and 43.3% for the radiotherapy group. The toxic side effects of chemotherapy are mainly gastrointestinal reactions and bone marrow suppression. The toxic side effects of radiotherapy are mainly radiation esophagitis, pneumonia and pulmonary fibrosis.