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目的:研究石家庄地区献血者RhD阴性血清学表型分布和不规则抗体检出情况。方法:对2015-01-2015-12石家庄地区无偿献血者标本,进行RhD阴性血筛查,确认血清学表型鉴定和不规则抗体筛选。结果:172 515例献血者标本中筛查出892例RhD阴性(0.52%),经确认为831例RhD阴性(0.48%),D变异型61例(6.84%),表型鉴定结果为ccdee 514例(57.62%)、Ccdee 222例(24.89%)、ccdEe 50例(5.61%)、CCdee 34例(3.81%)、CcdEe 20例(2.24%)、CCdEe 2例(0.22%);筛查出的892例RhD阴性标本中检出不规则抗体26例(2.8%)。结论:对献血者进行Rh阴性血筛查、确认,血清学表型鉴定和不规则抗体筛选对保障安全用血具有重要意义。
Objective: To study the distribution of RhD negative serological phenotypes and detection of irregular antibodies in blood donors in Shijiazhuang. Methods: RhD-negative blood samples were collected from unpaid blood donors in Shijiazhuang from January 2015 to December 2015 with confirmed serological phenotypes and irregular antibody screening. Results: Of the 5,152 blood donors, 892 RhD negatives (0.52%) were screened out, 831 RhD negatives (0.48%) and 61 (6.84%) D mutants were identified. The phenotypic identification results were ccdee 514 (57.62%), Ccdee 222 cases (24.89%), ccdEe 50 cases (5.61%), CCdee 34 cases (3.81%), CcdEe 20 cases (2.24%) and CCdEe 2 cases Of the 892 RhD-negative specimens, 26 were found to be irregular (2.8%). Conclusion: Rh-negative blood screening, confirmation, serological phenotyping and screening of irregular antibodies on blood donors are of great significance for ensuring safe blood use.