内容摘要——女性刺激素最初系从馬尿中提出,但从动物身体各部提出性刺激素,因含量少,杂質多,原料收集不易,甚为困难。約在20年前,作者等即行試用易得大量的胆脂醇(Cholesterol)作原料合成女性刺激素,其问题是在如何使天然物分子中A圈变为芳香核。当时計划中唯一的根据是麦角醇(Ergosterol)能变为新麦角醇(Neoergosterol),即碳圈中如有兩个双鍵或可使其变芳香核。作者等用胆脂醇衍化物(Cholestadienone)得到了实驗上经验后,即用削去胆脂醇边 Summary of Contents - Female stimulants were originally proposed in horse urine, but sexual stimulants have been proposed by the various animal body departments. Because of the low content and impurities, raw materials are not easily collected and it is difficult. About 20 years ago, the authors tried to synthesize female stimulants by using a large amount of Cholesterol as a raw material. The problem was how to turn the A-ring of natural molecules into aromatic nucleus. The only basis for the plan at the time was that Ergosterol could be converted to Neoergosterol, ie if there were two double bonds in the carbon ring or it could be made aromatic. The authors used the Cholestadienone with experimental experience to cut off the cholesterol