论文部分内容阅读
目的:探讨甲状腺乳头状癌中缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)和VEGF-C表达的临床意义。方法:应用免疫组织化学法检测73例甲状腺乳头状癌(Ⅰ组)、32例甲状腺腺瘤(Ⅱ组)和35例结节性甲状腺肿(Ⅲ组)患者中HIF-1α、VEGF和VEGF-C的表达。结果:HIF-1α在Ⅰ、Ⅱ和Ⅲ组中的表达率分别为75.3%、18.8%和14.3%;VEGF分别为72.6%、18.8%和20.0%;VEGF-C分别为65.8%、15.6%和11.4%;Ⅰ组的表达率均明显高于Ⅱ、Ⅲ组(均P<0.01)。甲状腺乳头状癌中有淋巴结转移的患者HIF-1α、VEGF和VEGF-C表达均高于未发生淋巴结转移者(均P<0.05),HIF-1α、VEGF与VEGF-C的表达存在相关性(P<0.05)。结论:甲状腺乳头状癌中HIF-1α、VEGF和VEGF-C的表达明显上调,且VEGF、VEGF-C的表达可能由HIF-1α调节,共同参与淋巴结转移的过程。
Objective: To investigate the clinical significance of the expression of hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and VEGF-C in papillary thyroid carcinoma. Methods: The expressions of HIF-1α, VEGF and VEGF-C in 73 cases of thyroid papillary carcinoma (group Ⅰ), 32 cases of thyroid adenoma (group Ⅱ) and 35 cases of nodular goiter (group Ⅲ) were detected by immunohistochemistry C expression. Results: The expression rates of HIF-1α in group Ⅰ, Ⅱ and Ⅲ were 75.3%, 18.8% and 14.3% respectively; VEGF were 72.6%, 18.8% and 20.0%; VEGF-C was 65.8% and 15.6% 11.4% respectively. The expression rate of group Ⅰ was significantly higher than that of group Ⅱ and Ⅲ (all P <0.01). The expression of HIF-1α, VEGF and VEGF-C in patients with lymph node metastasis of papillary thyroid carcinoma were significantly higher than those without lymph node metastasis (all P <0.05). The expression of HIF-1α, VEGF and VEGF- P <0.05). Conclusion: The expression of HIF-1α, VEGF and VEGF-C in thyroid papillary carcinoma was significantly up-regulated. The expression of VEGF and VEGF-C may be regulated by HIF-1α and participate in the process of lymph node metastasis.