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目的:观察伤科止痛膏对大鼠急性软组织损伤后损伤组织中一氧化氮(NO)和超氧化物歧化酶(SOD)影响以及局部软组织的形态学改变。方法:采用机械冲击挫伤的造模方法,建立大鼠急性软组织损伤模型,分别应用伤科止痛膏及扶他林乳膏涂布患处,并于治疗后第1,3,5天取材,测定大鼠损伤症侯指数、组织学及形态计量学指标,同时测定损伤组织中NO和SOD含量。结果:伤科止痛膏对急性软组织损伤动物模型有良好的恢复作用,给药组在损伤症侯指数、组织学恢复方面优于模型对照组,并能显著抑制损伤组织NO含量的升高(P<0.01),增高损伤组织SOD活性(P<0.01)。结论:伤科止痛膏治疗急性损伤的疗效机制之一与增高损伤组织SOD活性,降低局部软组织细胞释放的自由基NO含量有关。
Objective: To observe the effects of Shangkezhitong cream on nitric oxide (NO) and superoxide dismutase (SOD) and the morphological changes of local soft tissues in rats after acute soft tissue injury. Methods: Acute soft tissue injury model was established by using mechanical impact contusion modeling. The wounds were treated with Shangke Zhitong cream and Fufutin cream, and the wounds were harvested on the 1st, 3rd and 5th day after the treatment Symptoms index, histology and morphometry were used to determine the content of NO and SOD in injured tissues. Results: The Injury and Relieving Pain Decoction can restrain the animal model of acute soft tissue injury. The administration group is superior to the model control group in terms of the index of injury symptom and histological recovery, and can significantly inhibit the increase of NO content <0.01), and increased SOD activity in injured tissue (P <0.01). Conclusion: One of the therapeutic mechanisms for the treatment of acute injury with Shangke Zhitong cream is related to increasing the activity of SOD and decreasing the content of free radical NO in local soft tissue cells.