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表没食子儿茶素没食子酸酯(epigallocatechin-3-gallate,EGCG)是绿茶的主要成分之一。研究表明,EGCG具有抗氧化、预防癌症、抗炎、抗菌等作用。近年来,心脑血管疾病已成为当今世界影响人类健康最显著的疾病,而目前仅有少数神经保护药物能够用于治疗缺血性中风。很多基础研究证实,EGCG对于心脑血管缺血再灌注损伤具有独特的疗效,主要体现在调节氧化应激、抗细胞凋亡、抗炎、激活腺苷受体、降低血脑屏障的通透性及降低基质金属蛋白酶-9(MMP-9)表达等方面。针对EGCG对心脑血管缺血再灌注损伤保护作用机制进行综述,以期能为有效治疗心脑血管缺血性疾病药物的开发提供参考。
Epigallocatechin-3-gallate (EGCG) is one of the main components of green tea. Studies have shown that EGCG has anti-oxidant, anti-cancer, anti-inflammatory, antibacterial and other effects. In recent years, cardiovascular and cerebrovascular diseases have become the most prominent diseases affecting human health in the world today. Only a few neuroprotective drugs can be used to treat ischemic stroke. Many basic researches confirm that EGCG has a unique therapeutic effect on cardiovascular and cerebral ischemia-reperfusion injury, which is mainly reflected in the regulation of oxidative stress, anti-apoptosis, anti-inflammation, activation of adenosine receptor and decrease of permeability of blood-brain barrier And reduce the expression of matrix metalloproteinase-9 (MMP-9). In view of the protective mechanism of EGCG on cardiovascular and cerebrovascular ischemia-reperfusion injury, we hope to provide a reference for the development of drugs for the effective treatment of cardiovascular and cerebrovascular ischemic diseases.