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目的探索育龄妇女及母婴麻疹的IgG抗体水平,为科学地制定预防麻疹措施、降低育龄妇女及母婴麻疹发病提供指导。方法选取2013年4月至2016年8月于开封市祥符区第一人民医院产科随机选取的120名产妇及所生新生儿及在我院妇保门诊随机抽取的120名育龄妇女作为研究对象,对产妇及其新生儿、育龄妇女进行外周静脉采血测定麻疹IgG的抗体水平以及问卷调查。结果研究发现,血清麻疹IgG抗体阳性人数率、保护人数率、几何抗体平均浓度(GMC)新生儿组最高,育龄妇女组第二,妊娠母亲组最低,差异均有统计学意义(P<0.05)。不同年龄、户籍、文化程度的产妇麻疹IgG抗体水平差异均无统计学意义(P>0.05)。自然感染、接种疫苗以及自然产生抗体3组麻疹IgG抗体阳性率及保护率差异均无统计学意义(P>0.05),麻疹自然感染母亲抗体水平高于接种疫苗母亲以及无自然感染麻疹且无接种疫苗母亲的抗体水平(P<0.05)。母亲麻疹IgG抗体水平与新生儿麻疹IgG抗体水平有显著的正相关(r=0.862,P<0.01)。结论母亲麻疹IgG抗体水平是影响婴儿麻疹发病率的重要原因,因此我院建议育龄妇女进行麻疹疫苗接种,从而提高婴儿胎传抗体水平。
Objective To explore the level of IgG antibodies in women of childbearing age and maternal and measles, and to provide guidance for the scientific development of measles prevention measures and the reduction of the incidence of measles and maternal age in women of childbearing age. Methods From April 2013 to August 2016, 120 maternal and newborn infants randomly selected from obstetrics of First People’s Hospital, Xiangfu District, Kaifeng City, and 120 women of childbearing age randomly selected from women’s health insurance clinics in our hospital were selected as research subjects , The mothers and their newborns, women of childbearing age peripheral venous blood determination measles IgG antibody levels and questionnaires. Results The study found that the positive rate of serum measles IgG antibody, the protection rate, the highest geometric mean antibody (GMC) neonatal group, the second highest in reproductive age group and the lowest in pregnant mothers group were statistically significant (P <0.05) . There was no significant difference in the levels of IgG antibodies to measles among different age, household registration and educational level (P> 0.05). There were no significant differences in the positive rate and the protection rate of natural measles antibody among the three groups (P> 0.05), natural infection, vaccination and naturally occurring antibody (P> 0.05). The antibody level of spontaneous maternal antibody in measles was higher than that of vaccinated mother and non-naturally infected measles Antibody levels of the vaccine mother (P <0.05). There was a significant positive correlation between maternal measles IgG antibody levels and neonatal measles IgG antibody levels (r = 0.862, P <0.01). Conclusion Maternal measles IgG antibody level is an important factor affecting the incidence of measles in infants. Therefore, our hospital recommends that women of childbearing age should be immunized with measles to improve their level of fetal antibodies.