目的:研究马钱子配伍苏木不同比例水煎剂中马钱子碱和士的宁的含量变化。方法:采用高效液相色谱法分别对配伍前后主要生物碱成分马钱子碱和士的宁的质量分数进行测定。结果:与马钱子单煎剂相比,马钱子苏木1∶2、1∶4、1∶6煎剂中马钱子碱含量分别降低68.8%、76.8%、99.3%;士的宁含量分别下降56.8%、66.9%和93.6%。结论:通过配伍苏木,可降低马钱子毒性成分,起到减毒作用。减毒较佳配比为马钱子苏木1:6。 OBJECTIVE: To study the content changes of strychnine and strychnine in different proportion of decoction of Strychnos nux-vomica and hematoxylin. Methods: The contents of major alkaloids, strychnine and strychnine, before and after compatibility were determined by high performance liquid chromatography. Results: Compared with Strychni decoction, the contents of brucine in 1: 2, 1: 4, 1: 6 decoction of Strychnos nux-vomica decreased by 68.8%, 76.8% and 99.3% Content decreased 56.8%, 66.9% and 93.6% respectively. Conclusion: Through the compatibility of hematoxylin, it can reduce the toxic components of Strychnos nuitum and play an attenuating role. Better ratio of attenuated Strychnos 1: 6.