论文部分内容阅读
目的:探讨脑钠肽水平与糖尿病肾病(DN)之间的关系。方法:2型糖尿病组82例,根据内生肌酐清除率(Ccr)分为肾功能正常组(Ccr≥90 ml/min)、肾功能轻度减退组(60ml/min≤Ccr<90 ml/min)、肾功能重度减退组(Ccr<60 ml/min),设正常对照组30名。测定各组脑钠肽水平,同时观察各组间年龄、血肌酐、血脂、糖化血红蛋白(GHbA1c)等因素对脑钠肽水平的影响。结果:肾功能正常组、肾功能轻度减退组和肾功能重度减退组患者血清脑钠肽水平比较差异具统计学意义[(57±47)ng/L对比(87±44)ng/L对比(470±573)ng/L,P均<0.01]。2型糖尿病患者脑钠肽水平与年龄(r=0.315,P=0.004)、Ccr(r=-0.484,P=0.000)、血肌酐(r=0.580,P=0.000)显著相关。结论:2型糖尿病患者肾功能下降可能会引起脑钠肽浓度升高。故测定脑钠肽水平可能成为评估DN的辅助手段。
Objective: To investigate the relationship between brain natriuretic peptide and diabetic nephropathy (DN). Methods: 82 patients with type 2 diabetes mellitus were divided into normal renal function group (Ccr≥90 ml / min) and mild renal dysfunction group (60ml / min≤Ccr <90 ml / min) according to the endogenous creatinine clearance rate (Ccr) ), Severe renal dysfunction group (Ccr <60 ml / min), 30 normal control group. The levels of brain natriuretic peptide in each group were measured. At the same time, the effects of age, serum creatinine, blood lipid and glycosylated hemoglobin (GHbA1c) on brain natriuretic peptide were observed. Results: The levels of serum brain natriuretic peptide in patients with normal renal function group, mild renal dysfunction group and severe renal dysfunction group were significantly different [(57 ± 47) ng / L vs. (87 ± 44) ng / L) (470 ± 573) ng / L, P <0.01]. Brain natriuretic peptide was significantly associated with age (r = 0.315, P = 0.004), Ccr (r = -0.484, P = 0.000) and serum creatinine (r = 0.580, P = 0.000) in patients with type 2 diabetes. Conclusion: The decline of renal function in type 2 diabetic patients may cause the increase of brain natriuretic peptide concentration. Therefore, determination of brain natriuretic peptide levels may be an adjunct to assessing DN.