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目的:研究不同工艺制备的茜草提取物对小鼠止血作用的影响。方法:采用剪尾法测定正常小鼠的出血时间,采用毛细管法测定正常小鼠的凝血时间。结果:两种茜草提取物(高、低剂量组)均能缩短小鼠的出血时间和凝血时间(P<0.01),与粗提物(低剂量组)相比,茜草精制物的作用具有显著性差异(P<0.05)。结论:茜草粗提物和精制物均具有止血作用,且精制物效果更为明显,为其临床应用的样品制备工艺条件提供了实验依据。
Objective: To study the effects of Rubia cordifolia extracts prepared by different techniques on hemostasis in mice. Methods: The bleeding time of normal mice was determined by tail-cut method and the coagulation time of normal mice was determined by capillary method. Results: Both Rubia cordifolia extracts (high and low dose groups) could shorten the bleeding time and clotting time (P <0.01). Compared with the crude extracts (low dose group), the Rubia cordifolia plants had significant effects Sex differences (P <0.05). Conclusion: Rubia cordifolia extract and refined products have a hemostatic effect, and the effect of the refined substance is more obvious, which provides experimental evidence for clinical application of sample preparation process conditions.