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大约30％的乳腺癌转移在皮肤,且可作为乳腺癌的首发症状。多种免疫组化标记如雌激素受体(ER)、孕酮受体(PR)和BRST-2等可用来鉴别乳腺分化的肿瘤及判断其激素依赖状态。然而,随着肿瘤恶性程度增加及分化性丧失,其检测结果对判断转移癌的原发部位,则价值不大。为此,作者运用免疫组化方法同时检测了14例皮肤转移性乳腺癌(浸润性导管癌10
About 30% of breast cancer metastasizes to the skin and can be the first symptom of breast cancer. A variety of immunohistochemical markers such as estrogen receptor (ER), progesterone receptor (PR), and BRST-2 can be used to identify breast differentiated tumors and determine their hormone-dependent status. However, as the malignancy of the tumor increases and the differentiation is lost, the test results are of little value in determining the primary site of metastatic cancer. To this end, the authors used immunohistochemistry to simultaneously detect 14 cases of metastatic breast cancer (invasive ductal carcinoma 10