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4,4′-亚甲基双(2-氯苯胺)(MOCA)作为合成橡胶和环氧树脂的熟化剂在很多国家广泛应用,但 MOCA 是动物致癌剂,且被 IARC 列为人类潜在致癌剂[1]。近年来,对化学物致癌作用与机体内细胞色素 P448(Cyt P448)活性诱导之间的关系已有较深入的研究,但报导较多的为化学致癌
4,4’-Methylenebis (2-chloroaniline) (MOCA) is widely used as a curing agent for synthetic rubber and epoxy resins in many countries, but MOCA is an animal carcinogen and listed by IARC as a potential human carcinogen [1]. In recent years, the relationship between the carcinogenic effect of chemicals and the induction of cytochrome P448 (Cyt P448) activity in vivo has been studied in more depth, but more reports of chemical carcinogenesis