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本文以50例正常人为对照组与50例食道癌、宫颈癌患者和30例经~(60)Co射线放疗的癌症患者外周血淋巴细胞的染色体畸变率(CAs)进行了比较研究。发现放疗前患者的CAs比正常人明显升高,而放疗后的患者,CAs又明显高于放疗前的患者,这些都说明了CAs不仅可作为癌症患者的细胞遗传标记物,而且也能检测由~(60)Co射线所诱导的遗传学效应。肿瘤的发生和射线的局部照射同样影响了患者的外周血淋巴细胞。
In this study, we compared the chromosome aberration rates (CAs) of peripheral blood lymphocytes from 50 normal controls and 50 esophageal and cervical cancer patients and 30 cancer patients treated with ~ (60) Co radiation. Found that patients with CAs before radiotherapy were significantly higher than normal, and CAs in patients after radiotherapy was significantly higher than those before radiotherapy, which shows that CAs can not only be used as a cytogenetic marker for cancer patients, but also can be detected by ~ (60) Co radiation induced by the genetic effect. Tumor incidence and local radiation exposure also affect the patient’s peripheral blood lymphocytes.