论文部分内容阅读
目的 研究探讨强烈化疗后Ⅳ度骨髓抑制患者的救治方法。方法 化疗后当绝对粒细胞计数 (ANC)≤ 0 .5× 10 9/L时 ,对患者采取保护性隔离 ,应用粒细胞刺激因子 (G CSF)、抗菌素等直至血象恢复至ANC≥ 2 .0× 10 9/L。当出现感染性发热时抗菌素应用至感染控制。结果 共救治 72例患者 ,ANC≤ 0 .5× 10 9/L的中位持续天数为 3天 ,保护性隔离的中位天数为 6天。抗菌素应用的中位天数为 6天 ,G CSF应用的中位天数为 5天。 7例接受了血小板输注。 2 8例出现感染性发热 ,1例死于感染性休克。结论 对于强烈化疗后Ⅳ度骨髓抑制患者 ,及时采取保护性隔离 ,应用G CSF、抗菌素、输注血小板等综合处理 ,患者可安全、快速渡过危险阶段。
Objective To study the treatment of patients with IV myelosuppression after intensive chemotherapy. Methods After chemotherapy, when the absolute granulocyte count (ANC) ≤ 0 .5 × 10 9/L, the patient was subjected to protective isolation, using granulocyte stimulating factor (G CSF), antibiotics, etc. until the hemogram recovered to ANC ≥ 2.0. × 10 9/L. Antibiotics are applied to infection control when infectious fever occurs. Results A total of 72 patients were treated, and the median duration of ANC ≤ 0·5×10 9/L was 3 days, and the median time of protective isolation was 6 days. The median number of days for antibiotic application was 6 days, and the median number of days for G CSF application was 5 days. Seven patients received platelet transfusions. Twenty-eight patients developed infectious fever and one patient died of septic shock. Conclusion For patients with IV degree myelosuppression after intensive chemotherapy, protective isolation is applied in time, and G CSF, antibiotics, platelet transfusion and other comprehensive treatment are used. Patients can safely and quickly pass through the dangerous phase.