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目的:探讨联合输注新鲜冰冻血浆(FFP)和冷沉淀凝血因子用于肝肿瘤术后凝血功能异常患者的止血效果。方法:将120例肝肿瘤术后凝血功能异常患者随机分为3组:FFP单独输注组、冷沉淀凝血因子单独输注组及FFP和冷沉淀凝血因子联合输注组,每组各40例。所有患者住院期间均行肝肿瘤切除术,术后进行常规治疗,联合或单独输注FFP和冷沉淀凝血因子,3组分别于输注前1h及输注后24h静脉采血,检测输注前后凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)。结果:3组输注后PT、APTT、TT、FIB和输注前1h比较均差异有统计学意义(均P<0.01);与2个单独输注组比较,联合输注组PT、APTT、TT数值均差异有统计学意义(均P<0.05),FIB数值与FFP单独输注组比较也有明显提高(P<0.05)。结论:联合或单独给肝肿瘤术后凝血功能异常患者进行输注均能改善患者的凝血功能,联合输注的止血效果要好于单独输注一种成分。
Objective: To investigate the hemostatic effect of co-infusion of fresh frozen plasma (FFP) and cryoprecipitated coagulation factor in patients with abnormal coagulation after liver cancer surgery. Methods: One hundred and twenty patients with abnormal coagulation after liver tumor surgery were randomly divided into three groups: FFP alone infusion group, cryoprecipitated coagulation factor alone infusion group and FFP and lyophilized clotting factor combined infusion group, 40 cases in each group. . Liver tumor resection was performed in all patients during hospitalization. Routine treatment was performed postoperatively. FFP and cryoprecipitated coagulation factors were infused in combination or alone. Blood was collected from the three groups at 1 hour before infusion and 24 hours after infusion. Coagulation was measured before and after infusion. Protasome time (PT), partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB). Results: There was significant difference in PT, APTT, TT, FIB and 1h before infusion (P<0.01) between the 3 groups after infusion. Compared with 2 infusion groups, PT, APTT, The TT values were statistically significant (all P<0.05), and the FIB values were also significantly higher than those of the FFP alone infusion group (P<0.05). Conclusions: Infusion of patients with coagulopathy after combined or separate liver cancer surgery can improve the coagulation function of patients. The combined hemostasis is better than the single infusion of one component.