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目的探讨卡前列素氨丁三醇联合缩宫素预防高危因素剖宫产产后出血的临床效果。方法选择120例有出血倾向的高危孕妇,随机分为观察组和对照组各60例。两组孕妇全部采取剖官产手术方法,观察组手术后给予卡前列素氨丁三醇并缩宫素治疗;对照组在手术后采用缩宫素治疗。比较两组孕产妇剖宫产术后2 h及产后24 h的出血量,同时观察卡前列素氨丁三醇使用前后血压变化情况。结果剖宫产术后2 h及产后24 h的出血量观察组明显少于对照组(P<0.05);卡前列素氨丁三醇使用前后血压无明显变化(P>0.05)。结论卡前列素氨丁三醇能有效预防高危妊娠剖宫产产后出血,且用药安全、方便,易掌握,副反应小,值得临床推广。
Objective To investigate the clinical effects of combining carboprost with oxytocin and oxytocin in the prevention of cesarean section postpartum hemorrhage with high risk factors. Methods 120 cases of high risk pregnant women with bleeding tendency were randomly divided into observation group and control group of 60 cases. All pregnant women took cesarean section operation method, the observation group after surgery given carboprost tromethamine and oxytocin treatment; control group after surgery using oxytocin treatment. The amount of bleeding at 2 h after cesarean section and at 24 h after delivery were compared between the two groups. The changes of blood pressure before and after the use of carboprost trometamol were also observed. Results The amount of bleeding in 2 h after cesarean section and 24 h after delivery was significantly lower in the observation group than in the control group (P <0.05). There was no significant change in the blood pressure before and after the use of carboprost trinitrate (P> 0.05). Conclusion Cardutilin trometamol can effectively prevent cesarean section postpartum hemorrhage in high-risk pregnancies, and is safe, convenient and easy to handle, with less side effects and worthy of clinical promotion.