论文部分内容阅读
目的探讨冠心病患者血清中HMGB1和CRP水平与冠心病患者冠脉斑块形态及冠心病病情的关系。方法选择2015年8月-2016年8月本院收治的92例冠心病患者作为研究对象,采用酶联免疫吸附法检测患者血清中HMGB1和CRP水平,行冠状动脉造影评价患者冠心病病情,行冠脉CT判断冠状动脉斑块性质,探讨患者血清中HIMGB1和CRP水平与患者冠脉性质和冠心病病情的关系。结果根据HMGB1和CRP中位数分为高水平组和低水平组,HMGB1高水平组、CRP高水平组患者冠脉软斑块均多于对应低水平组;HMGB1高水平组患者冠脉多支病变数多于低水平组,CRP高水平组患者冠脉重度闭塞、完全闭塞数多于对应低水平组患者,差异均有统计学意义(P<0.05)。结论高水平的HMGB1和CRP患者冠脉病变程度越严重,软斑块发病率越高。
Objective To investigate the relationship between serum levels of HMGB1 and CRP and coronary plaque morphology and coronary heart disease in patients with coronary heart disease. Methods 92 patients with coronary heart disease admitted to our hospital from August 2015 to August 2016 were enrolled in this study. Serum levels of HMGB1 and CRP were measured by enzyme-linked immunosorbent assay (ELISA), and coronary artery disease (CAD) was evaluated by coronary angiography. Coronary artery plaque judgment of coronary artery plaque characteristics of patients with serum HIMGB1 and CRP levels in patients with coronary artery disease and coronary heart disease. The results were divided into high-level group and low-level group according to the median of HMGB1 and CRP. The patients with HMGB1 high level and CRP high level group had more coronary soft plaque than the corresponding low-level group. Patients with high CRP levels had more severe coronary occlusion and more complete occlusion than those with low level of CRP. The difference was statistically significant (P <0.05). Conclusion The severity of coronary lesion is more serious in patients with high level of HMGB1 and CRP, and the incidence of soft plaque is higher.