论文部分内容阅读
至今已知大约有三十种肽(低分子量、单链氨基酸化合物)广泛地分布于中枢神经系统的选择性神经通路内.有证据说明P物质和阿片样肽在痛觉的传导及调节上,特别是在脊髓的水平上,起主要作用.血管活性肠多肽在控制脑循环,缩胆囊肽对调节食欲,血管加压素及促肾上腺皮质激素对记忆,以及阿片样肽在癫痫发作的发病机制上的作用.对大多数肽来说,至今还很少资料说明它们的生物合成、释放、与受体的相互作用以及生物效应的终止等机转.另一个重要的问题是肽类与其他神经递质的相互关系.
To date, it has been known that about thirty peptides (low molecular weight, single-stranded amino acid compounds) are widely distributed in the central nervous system’s selective neural pathways. There is evidence that substance P and opioid peptides are involved in the conduction and regulation of pain, Plays a major role at the level of the spinal cord Vasoactive intestinal polypeptide plays a key role in the control of the cerebral circulation, the regulation of appetite by cholecystokinin, vasopressin and adrenocorticotropic hormone on memory, and the pathogenesis of opioid peptides in seizures For most peptides, little information is available on the mechanisms of their biosynthesis, release, interaction with receptors and the termination of biological effects etc. Another important issue is the interaction between peptides and other neurotransmitters The relationship between quality.