论文部分内容阅读
目的探讨新疆巴楚县维吾尔族妇女宫颈病变检出率和HPV感染率与当地土壤中微量元素的相关性,为新疆维吾尔族宫颈癌的防治提供基础。方法 2014年3月1日-6月15日随机选择巴楚县9个乡镇,每个乡镇选取农田土壤42处,包括红枣、小麦和玉米地,采集的土壤样品采用原子吸收发光法对Cu、Zn、Fe、Ni、Se进行检测,土壤中微量元素水平与维吾尔族妇女宫颈病变检出率和HPV感染率相关性采用偏相关分析。结果新疆喀什地区巴楚县维吾尔族妇女HPV感染阳性率为9.3%,宫颈高级别病变及宫颈癌的检出率为1.33%。土壤中Ni、Cu、Zn、Se和Fe微量元素水平的均值均未超过中华人民共和国国家环境土壤标准。土壤中Cu水平与宫颈高级别病变及宫颈癌检出率呈正相关(rs=0.498,P=0.019),Se水平与维吾尔族妇女宫颈病变检出率呈负相关(rs=-0.461,P=0.041),土壤中Se水平与维吾尔族妇女HPV感染率呈负相关(rs=-0.522,P=0.040)。结论土壤中缺硒、富铜可能与新疆巴楚县维吾尔族妇女宫颈高级别病变、宫颈癌与HPV感染有关。
Objective To investigate the correlation between the detection rate of cervical lesions and HPV infection in local Uighur women in Bachu County, Xinjiang and the trace elements in the local soil so as to provide the foundation for the prevention and treatment of Uygur cervical cancer in Xinjiang. Methods From March 1 to June 15, 2014, 9 villages and townships in Bachu County were selected at random. Forty-two soils including red dates, wheat and corn fields were selected for each township. The collected soil samples were subjected to atomic absorption spectrometry Zn, Fe, Ni and Se. The correlation between trace element levels in soil and the detection rate of cervical lesions and HPV infection in Uighur women was analyzed by partial correlation analysis. Results The positive rate of HPV infection in Uygur women in Bachu County, Kashgar region of Xinjiang was 9.3%. The detection rate of high grade cervical lesions and cervical cancer was 1.33%. The mean levels of trace elements Ni, Cu, Zn, Se and Fe in soils did not exceed the national environmental standards of the People’s Republic of China. The level of Cu in soil was positively correlated with the high grade cervical lesions and the positive rate of cervical cancer (rs = 0.498, P = 0.019). Se levels were negatively correlated with the detection rate of cervical lesions in Uighur women (rs = -0.461, P = 0.041 ). The level of Se in soil was negatively correlated with the HPV infection rate of Uigur women (rs = -0.522, P = 0.040). Conclusion The lack of selenium and copper in soil may be related to the high grade cervical lesions, cervical cancer and HPV infection among Uygur women in Bachu County, Xinjiang.