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目的:观察分析阿司匹林与阿伐他汀联用治疗短暂性脑缺血的临床疗效。方法:随机选取于2013年8月-2015年5月来我院就诊的短暂性脑缺血患者70例,随机分为观察组(37例)和对照组(33例),两组患者均给予包括维生素C、低分子质量肝素等常规治疗,同时观察组患者给予阿司匹林(100 mg)和阿伐他汀(20 mg)联合用药,口服,一日1次。对照组仅给予阿司匹林(100 mg)进行治疗,口服,一日1次。两组患者的治疗周期均为30天,观察比较两组患者的临床疗效,血液流变学指标(全血粘度、血细胞比容、血浆粘度),神经功能恢复状况及不良反应发生状况,并随访6个月。结果:治疗结束后,观察组患者的总体有效率(94.59%)显著高于对照组患者(72.73%),差异具有统计学意义(P<0.05),两组患者的血液流变学指标均较治疗前降低,且观察组患者的血液流变学指标降低情况显著高于对照组患者(P<0.05),两组患者治疗期间总体不良反应发生率均较低,随访中,治疗组患者的复发率显著低于对照组患者(5.88%vs 25.88%)。结论:阿伐他汀联合阿司匹林治疗短暂性脑缺血治疗效果更显著,且安全性较好。
Objective: To observe and analyze the clinical efficacy of aspirin and atorvastatin in the treatment of transient cerebral ischemia. Methods: Seventy patients with transient ischemic attack who were admitted to our hospital from August 2013 to May 2015 were randomly divided into observation group (37 cases) and control group (33 cases), and both groups were given Including vitamin C, low molecular weight heparin and other conventional treatment, while patients in the observation group were given aspirin (100 mg) and atorvastatin (20 mg) combination therapy, orally, once a day. Control group only given aspirin (100 mg) for treatment, orally, once a day. The two groups of patients were treated for 30 days. The clinical efficacy, hemorheological parameters (whole blood viscosity, hematocrit, plasma viscosity), recovery of neurological function and adverse reactions were observed and compared between the two groups 6 months. Results: After the treatment, the total effective rate (94.59%) in the observation group was significantly higher than that in the control group (72.73%), the difference was statistically significant (P <0.05). The hemorrheological indexes in both groups were significantly higher than those in the control group The decrease of hemorheology index in the observation group was significantly higher than that in the control group (P <0.05). The incidence of adverse reactions was lower in both groups during the treatment period. The recurrence rate of patients in the treatment group The rates were significantly lower in the control group (5.88% vs 25.88%). Conclusion: Atorvastatin combined with aspirin in the treatment of transient ischemic injury more effective and safe.