A simulated climate warming experiment was conducted to evaluate the combined effects of elevated temperature and CO_2 concentration on the bioaccumulation,translocation and subcellular distributions of Cd and Zn in wheat seedlings(Triticum aestivum L.cv.Xihan 1.) at Dingxi,Gansu Province,China.The objective was to find evidence that global climate change is affecting the bioaccumulation of Cd and Zn in T.aestivum L.cv.Xihan 1.The results showed that compared to control A,elevated temperature and CO_2 increased Cd bioaccumulation in the shoots by 1.4–2.5 times,and increased that in the roots by 1.2–1.5times,but decreased Zn levels in wheat shoots by 1.4–2.0 times,while decreased that in the roots by 1.6–1.9 times.Moreover,temperature and CO_2 concentration increase also led to increased Cd concentration,and decreased Zn concentration in subcellular compartments of wheat seedlings.The largest Cd concentration increase(174.4%) was observed in the cell wall and debris fractions of shoots after they were subjected to the highest CO_2 and temperature treatment(TC3).The largest Zn concentration decrease(53.1%) was observed in the soluble(F3) fractions of shoots after they were subjected to the medium CO_2 and temperature treatment(TC2).The temperature and CO_2 increase had no significant effect on the proportional distribution of Cd and Zn in the subcellular fractions.The root-to-shoot translocation of Cd increased with the increasing temperature and CO_2 concentration.However,the Zn distributions only fluctuated within a small range. A simulated climate warming experiment was conducted to evaluate the combined effects of elevated temperature and CO_2 concentration on the bioaccumulation, translocation and subcellular distributions of Cd and Zn in wheat seedlings (Triticum aestivum L.cv.Xihan 1.) at Dingxi, Gansu Province, China. The objective was to find evidence that global climate change is affecting the bioaccumulation of Cd and Zn in T. aestivum L.cv.Xihan 1. The results showed that compared to control A, elevated temperature and CO 2 increased Cd bioaccumulation in the shoots by 1.4-2.5 times, and increased that in the roots by 1.2-1.5times, but decreased decreased Zn levels in wheat shoots by 1.4-2.0 times, while decreased that in the roots by 1.6-1.9 times. Moverover, temperature and CO_2 concentration increase also led to increased Cd concentration, and decreased Zn concentration in subcellular compartments of wheat seedlings.The maximum Cd concentration increase (174.4%) was observed in the cell wall and debris fractions of shoots after they were subjected to the highest CO_2 and temperature treatment (TC3). The largest Zn concentration decrease (53.1%) was observed in the soluble (F3) fractions of shoots after they were subjected to the medium CO_2 and temperature treatment (TC2) The temperature and CO 2 increase had no significant effect on the proportional distribution of Cd and Zn in the subcellular fractions. The root-to-shoot translocation of Cd increased with increasing temperature and CO 2 concentration. However, the Zn distributions only fluctuated within a small range.