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[目的]探讨奥美拉唑治疗小儿胃食管反流性哮喘疗效及对肺功能、炎性因子、免疫功能的影响。[方法]入组胃食管反流性哮喘患儿86例依据随机数字表法随机分为观察组43例与对照组43例。2组均采用常规处理,对照组采用必可酮气雾剂治疗,观察组在对照组基础上结合奥美拉唑治疗。2组疗程均为8周。[结果]2组患儿胃食管反流症状和哮喘症状评分治疗后明显减少(P<0.05);观察组患儿胃食管反流症状和哮喘症状评分治疗后低于对照组(P<0.05);2组FEV1、PEF治疗后明显增加(P<0.05);2组FEV1、PEF治疗后高于对照组(P<0.05);2组患儿IL-5治疗后明显降低(P<0.05),IL-10治疗后明显增加(P<0.05);观察组患儿IL-5治疗后低于对照组(P<0.05),IL-10高于对照组(P<0.05);2组患儿CD3+、CD4+、CD4+/CD8+治疗后明显增加(P<0.05),CD8+治疗后明显降低(P<0.05);观察组患儿CD3+、CD4+治疗后高于对照组(P<0.05),CD8+治疗后低于对照组(P<0.05);2组均未见严重药物不良反应。[结论]奥美拉唑治疗小儿胃食管反流性哮喘疗效显著,可明显改善患儿肺功能、微炎症状态、免疫功能,改善具有重要研究价值。
[Objective] To investigate the therapeutic effect of omeprazole in children with gastroesophageal reflux disease and its effects on pulmonary function, inflammatory factors and immune function. [Methods] 86 cases of children with gastroesophageal reflux disease were randomly divided into observation group (43 cases) and control group (43 cases) according to the random number table method. The rats in both groups were treated routinely. The control group was treated with becquerelne aerosol. The observation group was treated with omeprazole on the basis of the control group. The two groups were treated for 8 weeks. [Results] The scores of gastroesophageal reflux symptom and asthma symptom in both groups were significantly decreased after treatment (P <0.05). The scores of gastroesophageal reflux symptom and asthma symptom in the observation group were lower than those in the control group (P <0.05) (P <0.05); FEV1, PEF after treatment in both groups increased significantly (P <0.05); FEV1 and PEF after 2 groups were higher than those in control group (P <0.05); IL- The levels of IL-10 in the observation group were significantly lower than those in the control group (P <0.05), IL-10 in the observation group was significantly higher than that in the control group (P <0.05) (P <0.05). After treatment with CD8 +, the levels of CD3 + and CD4 + in the observation group were significantly higher than those in the control group (P <0.05), while the levels of CD8 + and CD4 + / CD8 + In the control group (P <0.05). No serious adverse drug reactions were observed in the two groups. [Conclusion] Omeprazole is effective in treating children with gastroesophageal reflux disease and can significantly improve children ’s lung function, microinflammatory state and immune function, and has important research value.